Venezia host Fiorentina at the Stadio Penzo, looking for their first home win this season.
The Lagunari have only played two games at home so far, collecting one point.
Goalkeeper Niki Mäenpää is in doubt for the match while Luca Lezzerini is on the treatment table.
Therefore, new signing Sergio Romero will make his debut with the newly-promoted Serie A side, playing his first Serie A match since 2014.
The former Manchester United man joined Venezia on a free transfer during the break.
Fiorentina also have problems between the sticks with Bartlomiej Dragowski out of action with a thigh injury.
All eyes will be on Dusan Vlahovic as he will start his first game since Rocco Commisso announced the striker would not extend his contract with Fiorentina.
His deal at the Stadio Artemio Franchi expires in June 2023.
The Tuscans have won three of their four away games in 2021-22.
Form Guide: Venezia (D D L L W) Fiorentina (L W L W W)
Stat fact: Venezia won their last game against Fiorentina in Serie A, but it was almost 20 years ago, in February 2002.
Probable line-ups
Venezia (4-3-3): Romero; Mazzocchi, Caldara, Ceccaroni, Haps; Crnigoj, Vacca, Busio; Aramu, Henry, Johnsen
Suspended: none
Injured: Lezzerini
On a yellow card: Heymans
Fiorentina (4-3-3): Terraciano; Odriozola, Milenkovic, Martinez Quarta, Biraghi; Bonaventura, Pulgar, Duncan; Callejon, Vlahovic, Nico Gonzalez
Suspended: none
Injured: Dragowski
On a yellow card: Bonaventura