Lazio have to reinvent their midfield in a trip to giant-killers Sassuolo, as Gianluca Scamacca tries to prove a point against Ciro Immobile.
The Biancocelesti have Sergej Milinkovic-Savic suspended and Luis Alberto injured, therefore forcing a complete transformation of their midfield selection. They played a 0-0 Europa League draw with Galatasaray on Thursday and Immobile continues to grit his teeth through an on-going knee issue.
Sassuolo have made quite an impression against the big clubs this season, beating Juventus and Milan, with a comeback to draw 2-2 against Napoli. Scamacca is on sparkling form and goes head-to-head with Immobile for a role leading the Italy attack.
Form Guide: Sassuolo (D D W D L) Lazio (W D L L W)
Stat fact: Lazio have conceded 30 goals in their opening 16 Serie A games, their worst defensive start since 1958-59, when they finished 11th.
Probable line-ups
Sassuolo (4-3-3): Consigli; Toljan, Chiriches, Ferrari, Rogerio; Frattesi, Lopez, Henrique; Berardi, Scamacca, Raspadori
Suspended: None
Injured: Obiang, Romagna, Djuricic
On a yellow card: None
Lazio (4-3-3): Strakosha; Hysaj, Luiz Felipe, Acerbi, Marusic; Akpa-Akpro, Cataldi, Basic; Felipe Anderson, Immobile, Zaccagni
Suspended: Milinkovic-Savic
Injured: Luis Alberto
On a yellow card: Cataldi