Lazio have to reinvent their midfield in a trip to giant-killers Sassuolo, as Gianluca Scamacca tries to prove a point against Ciro Immobile.

The Biancocelesti have Sergej Milinkovic-Savic suspended and Luis Alberto injured, therefore forcing a complete transformation of their midfield selection. They played a 0-0 Europa League draw with Galatasaray on Thursday and Immobile continues to grit his teeth through an on-going knee issue.

Sassuolo have made quite an impression against the big clubs this season, beating Juventus and Milan, with a comeback to draw 2-2 against Napoli. Scamacca is on sparkling form and goes head-to-head with Immobile for a role leading the Italy attack.

Form Guide: Sassuolo (D D W D L) Lazio (W D L L W)

Stat fact: Lazio have conceded 30 goals in their opening 16 Serie A games, their worst defensive start since 1958-59, when they finished 11th.

Probable line-ups

Sassuolo (4-3-3): Consigli; Toljan, Chiriches, Ferrari, Rogerio; Frattesi, Lopez, Henrique; Berardi, Scamacca, Raspadori

Suspended: None

Injured: Obiang, Romagna, Djuricic

On a yellow card: None

Lazio (4-3-3): Strakosha; Hysaj, Luiz Felipe, Acerbi, Marusic; Akpa-Akpro, Cataldi, Basic; Felipe Anderson, Immobile, Zaccagni

Suspended: Milinkovic-Savic

Injured: Luis Alberto

On a yellow card: Cataldi

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