Sampdoria and Spezia are desperate for points ahead of the Liguria derby.
Thiago Motta’s side have collected seven points so far, while Sampdoria have six.
Roberto D’Aversa’s side are without a win in the last four matches, but the club have denied reports that they are considering the coach’s sacking.
Morten Thorsby will serve a one-match ban after collecting his fifth yellow card this season last week. Mikkel Damsgaard is still on the treatment table, but could return to action by the end of the month.
Spezia’s Jacopo Sala and Aurélien Nguiamba are in doubt for the match, but Spezia’s medical staff is busy with eight players unavailable due to injuries.
Form Guide: Sampdoria (L D L L W) Spezia (W L L L W)
Stat fact: Spezia and Sampdoria have only met twice in Serie A and Spezia are unbeaten with one win and a draw.
Sampdoria (4-4-2): Audero; Bereszynski, Yoshida, Colley, Augello; Candreva, Adrien Silva, Ekdal, Askildsen; Gabbiadini, Quagliarella
Injured: Vieira, Damsgaard
On a yellow card: Bereszynski
Spezia (4-2-3-1): Provedel; Ferrer, Hristov, Nikolaou, S Bastoni; Kovalenko, Maggiore; Strelec, Antiste, Gyasi; Nzola
Injured: Kiwior, Bourabia, Reca, Agudelo, Amian, Erlic, Leo Sena, Colley
On a yellow card: Nikolaou