Inter hope to make the most of the fixture list to break away at the top with a perfect record, but Sampdoria debut deadline day signing Ciccio Caputo.
The Nerazzurri have had an excellent start to the season under new coach Simone Inzaghi and aim to maintain that momentum, even if Lautaro Martinez is rested following international duty in Argentina. Stefano Sensi could step in for the 3-5-1-1 formation as support for Edin Dzeko, assuming his muscular issues are resolved.
Samp have just one point from the opening two rounds and failed to find the net, which is one of the reasons why they signed Caputo from Sassuolo on deadline day. He can be thrown straight in from the start, but Albin Ekdal and Bartosz Bereszynski remain in doubt.
Stat fact: Inter have won seven of their last eight Serie A meetings with Sampdoria, except for a 2-1 defeat here in January.
Probable line-ups
Sampdoria (4-4-2): Audero; Depaoli, Yoshida, Colley, Augello; Candreva, Silva, Thorsby, Damsgaard; Caputo, Quagliarella
Suspended: None
Injured: Gabbiadini, Torregrossa, Ekdal, Murru
On a yellow card: None
Inter (3-5-1-1): Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Dimarco; Sensi; Dzeko
Suspended: None
Injured: Eriksen
On a yellow card: None