The Partenopei sit only four points behind the Nerazzurri in the Serie A table and despite their injury crisis, picking up all three points is a must if they want to keep the gap to the Milanese club to a minimum.
An upset win would be key for Spezia, who sit only three points ahead of relegation candidates Genoa. The Ligurian side’s last win came in early November, when they beat Torino 1-0. Since then they have only picked up two points in their last six league outings.
Form Guide: Napoli (W L L D W) Spezia (D L D L L)
Stat fact: Napoli haven’t won any of their last eight league matches that were played on a Wednesday, drawing four and losing four. Their last win on a Wednesday came in July 2020, when they beat Genoa 2-1.
Napoli (4-2-3-1): Ospina; Mario Rui, Juan Jesus, Rrahmani, Di Lorenzo; Lobotka, Zambo Anguissa; Elmas, Zielinski, Lozano; Mertens
Injured: Koulibaly, Fabian Ruiz, Insigne, Osimhen
On a yellow card: Mario Rui, Zambo Anguissa
Spezia (3-5-2): Provedel; Amian, Erlic, Nikolaou; Gyasi, Maggiore, Kiwior, Kovalenko, Reca; Antiste, Colley
Injured: Leo Sena, Verde, Salcedo, Sala
On a yellow card: None