They were the joint leaders for much of the campaign, before a run of disappointing results and Inter’s surge saw them slide down. The pressure is therefore on to confirm their title ambitions at San Siro.
Theo Hernandez is in doubt after suffering from flu symptoms, while Olivier Giroud is only fit for a spot on the bench.
Luciano Spalletti has more concerns to deal with, as Mario Rui has been added to the absentee list, joining Lorenzo Insigne, Victor Osimhen, Kalidou Koulibaly and Fabian Ruiz. The Partenopei picked up just one point from the last three rounds.
Form Guide: Milan (D W W L L) Napoli (L L D W L)
Stat fact: Napoli are unbeaten away to Milan in Serie A since December 2014, leaving with three wins and as many draws.
Milan (4-2-3-1): Maignan; Florenzi, Tomori, Romagnoli, Ballo-Toure; Tonali, Kessie; Messias, Brahim Diaz, Krunic; Ibrahimovic
Injured: Calabria, Kjaer, Leao, Pellegri, Plizzari, Rebic
On a yellow card: None
Napoli (4-2-3-1): Ospina; Malcuit, Rrahmani, Juan Jesus, Di Lorenzo; Anguissa, Demme; Politano, Zielinski, Elmas; Mertens
Injured: Osimhen, Insigne, Koulibaly, Fabian Ruiz, Mario Rui
On a yellow card: Anguissa, Mario Rui