The Biancocelesti could be without their star striker and captain, in which case either Pedro or Felipe Anderson will take the False 9 role, as Maurizio Sarri doesn’t trust starting Vedat Muriqi. Sergej Milinkovic-Savic returns from suspension to bolster the midfield and they need confidence after the 2-1 defeat to Sassuolo.
Genoa are without a Serie A victory since the start of October, managing five draws in 11 rounds, but did squeeze past Salernitana 1-0 in the Coppa Italia on Tuesday. The big news is the return of Destro upfront, which should help stem the goal crisis, but Felipe Caicedo and Mohamed Fares won’t face their former club.
Form Guide: Lazio (L W D L L) Genoa (L L L D L)
Stat fact: Andriy Shevchenko is only the third coach in the three points for a win era who hasn’t won any of his first five Genoa games in Serie A after Giuseppe Marchioro in 1995 and Gigi Delneri in 2012.
Lazio (4-3-3): Strakosha; Hysaj, Luiz Felipe, Acerbi, Marusic; Milinkovic-Savic, Cataldi, Basic; Pedro, Felipe Anderson, Zaccagni
On a yellow card: Cataldi
Genoa (3-5-2): Sirigu; Vanheusden, Masiello, Criscito; Ghiglione, Sturaro, Badelj, Hernani, Cambiaso; Pandev, Destro
Injured: Rovella, Maksimovic, Fares, Kallon, Caicedo
On a yellow card: Biraschi, Sturaro