Juventus are close in on a Champions League spot, while strugglers Cagliari must react to a humiliating 4-0 defeat suffered last week.
The Bianconeri host Cagliari for the last game of the year at the Allianz Stadium.
They are without the injured Paulo Dybala, Aaron Ramsey, Giorgio Chiellini and Danilo.
All of them, except Ramsey, will return to training after the break, said Juventus coach Massimiliano Allegri.
Alex Sandro is likely to start at left-back with Moise Kean and Alvaro Morata up front.
Juan Cuadrado should rest as he is one yellow card away from suspension and the Old Lady face Napoli in the first game of 2022.
Cagliari suffered a 4-0 loss at home against Udinese last week and a group of ultras confronted the team after the game.
Martin Caceres and Diego Godin won’t travel to Turin as a punishment for their poor performances and in all fairness, their time on the island seems to be over.
Razvan Marin is suspended, Sebastian Walukiewicz, Marko Rog and Kevin Strootman are injured.
Form Guide: Juventus (W D W W L) Cagliari (L L D D D)
Stat fact: Juventus have won each one of the last five games at home against Cagliari, scoring 16 goals and conceding once.
Probable line-ups
Juventus (4-4-2): Szczesny; Cuadrado, De Ligt, Bonucci, Alex Sandro; McKennie, Locatelli, Rabiot, Bernardeschi; Morata, Kean
Suspended: none
Injured: Chiesa, Ramsey, Chiellini, Dybala, Danilo
On a yellow card: Cuadrado, Danilo
Cagliari (4-4-2): Cragno; Bellanova, Ceppitelli, Carboni, Lykogiannis; Zappa, Deiola, Grassi, Dalbert; Pavoletti, Joao Pedro
Suspended: Marin
Injured: Walukiewicz, Rog, Strootman
On a yellow card: Dalbert, Strootman