Nine points divide Atalanta and Roma in the Serie A table ahead of a crucial meeting in the race for the top four.
Robin Gosens is the only player out of action for La Dea who see Ruslan Malinovskyi return after serving a one-match ban.
The Ukraine star is likely to start along with Mario Pasalic behind the sole striker Duvan Zapata.
Atalanta are unbeaten against Roma in the last seven matches.
Smalling seems to have recovered from an injury and is expected to start in Roma’s three-man defence.
However, Afena-Gyan is suspended, while Leonardo Spinazzola, Lorenzo Pellegrini and Stephan El Shaarawy are still on the treatment table.
Roma lost three of their last four meetings against La Dea, but scored at least one goal in each one of their last 11 away games with La Dea.
Form Guide: Atalanta (W W W W W) Roma (W L L W W)
Stat fact: Roma have won four of the last 11 away games in Bergamo, with 3 draws and four defeats
Probable line-ups
Atalanta (3-4-2-1): Musso; Toloi, Demiral, Djimsiti; Maehle, De Roon, Freuler, Zappacosta; Pasalic, Malinovskyi; Zapata
Suspended: none
Injured: Gosens
On a yellow card: Freluer, Demiral
Roma (3-4-2-1): Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Veretout, Cristante, Vina; Mkhitaryan, Zaniolo; Abraham
Suspended: Afena-Gyan
Injured: Spinazzola, Pellegrini, El Sharaawy
On a yellow card: Cristante