Antonio Conte gives Giovanni Simeone and Khvicha Kvaratskhelia the keys to the Napoli attack, with Victor Osimhen awaiting transfer as they visit Verona.
It kicks off at the Stadio Bentegodi at 17.30 UK time (16.30 GMT).
You can follow all the build-up and action as it happens from this game, Bologna–Udinese, Cagliari–Roma and Lazio–Venezia on the LIVEBLOG.
The Partenopei already made their competitive debut under Conte in a disappointing 0-0 Coppa Italia draw with Serie B side Modena, only getting through to the next round thanks to a penalty shoot-out.
Alessandro Buongiorno sprained his ankle during that match and misses out, while Osimhen is effectively frozen out waiting for a transfer and Alessio Zerbin suspended.
Simeone is chosen as centre-forward rather than Giacomo Raspadori, supported by Kvaratskhelia and Matteo Politano.
Verona are also under new management, but Paolo Zanetti debuted with a 2-1 Coppa Italia defeat to Cesena.
It’s a revamped squad in attack, with Casper Tengstedt getting the nod ahead of Daniel Mosquera for the main role upfront.
Tomas Suslov is not at 100 per cent and Juan Manuel Cruz out of action, but Frese does recover to start.
Verona vs. Napoli line-ups
Verona: Montipò; Tchatchoua, Magnani, Coppola, Frese; Duda, Serdar; Kastanos, Livramento, Lazovic; Tengstedt
Napoli: Meret; Di Lorenzo, Rrhamani, Juan Jesus; Mazzocchi, Anguissa, Lobotka, Spinazzola; Politano, Kvaratskhelia; Simeone
Player statistic
| Diego Coppola |  |
20' | ||
| Jackson Tchatchoua | |
31' |
| Dailon Rocha Livramento (Assist: Darko Lazovic) |
 |
50' | ||
| Daniel Mosquera (Assist: Ondrej Duda) |
|
75' | ||
| Ondrej Duda | |
77' | ||
| 89' | |
Giacomo Raspadori | ||
| Reda Belahyane | |
90+1' | ||
| Daniel Mosquera (Assist: Darko Lazovic) |
|
90+4' |
Match statistic
