Milan start Luka Jovic, Joao Felix and Christian Pulisic, while Bologna rotate ahead of the Coppa Italia Final with Riccardo Orsolini and Benjamin Dominguez.
It kicks off at San Siro at 19.45 UK time (18.45 GMT, 20.45 CET).
You can follow all the build-up and action as it happens on the Liveblog.
By a curious twist of fate, these teams meet in Serie A tonight, while they will face off again in the Coppa Italia Final on Wednesday May 14 at the Stadio Olimpico in Rome.
With that in mind, both coaches are tempted to engage in some squad rotation.

You will also see some unusual jerseys, as the players honour Mother’s Day by wearing their parents’ maiden names on the back of their shirts.
Rafael Leao is suspended after coming off the bench to turn around last week’s 2-1 win over Genoa.
Youssouf Fofana, Warren Bondo and Riccardo Sottil are out injured, with Tammy Abraham still not at 100 per cent either.
Jovic and Joao Felix lead the attack with Pulisic, despite suggestions Santiago Gimenez would step into the starting XI.
Sergio Conceicao has now definitively adopted the 3-4-2-1 formation, using Theo Hernandez as a wing-back.

Bologna had been in fourth place a couple of weeks ago, but faltered with back-to-back draws against Udinese and Juventus.
Nonetheless, they remain only one point adrift of Juve in fourth.
Dan Ndoye, Emil Holm and Estanis Pedrola are injured, while Jens Odgaard is left at home to rest ahead of their first Coppa Italia Final in 51 years.
Santiago Castro is on the bench, so Thijs Dallinga starts with support from Orsolini and Benjamin Dominguez.
Former Milan captain Davide Calabria joined Bologna in January, but he watches initially from the bench, while another ex-Rossoneri player Tommaso Pobega does start.
Milan vs. Bologna line-ups
Milan: Maignan; Tomori, Gabbia, Pavlovic; Jimenez, Loftus-Cheek, Reijnders, Theo Hernandez; Pulisic, Joao Felix; Jovic
Bologna: Skorupski; De Silvestri, Erlic, Beukema, Lykogiannis; Freuler, Moro, Pobega; Orsolini, Dallinga, Dominguez
Player statistic
37' | ![]() |
Jhon Lucumí |
49' | ![]() |
Riccardo Orsolini (Assist: Thijs Dallinga) | ||
Ruben Loftus-Cheek | ![]() |
60' | ||
João Félix | ![]() |
67' | ||
Santiago Giménez (Assist: Christian Pulisic) |
![]() |
73' | ||
Christian Pulisic | ![]() |
79' | ||
Santiago Giménez (Assist: Samuel Chukwueze) |
![]() |
90+2' | ||
90+1' | ![]() |
Santiago Castro |
Match statistic


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