Inter need to get their Serie A season back on track, but Francesco Pio Esposito again partners Marcus Thuram upfront against Domenico Berardi’s Sassuolo.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
The Nerazzurri were in crisis after back-to-back Serie A defeats to Udinese and rivals Juventus, but there was a significant step forward in the midweek Champions League victory away to Ajax.
Now they need to bring some of that European form to domestic football, but Lautaro Martinez is still not fully fit after missing the Amsterdam clash with a back injury.
Young striker Esposito is therefore confirmed upfront with brace hero Thuram.
There is rotation elsewhere, with the return of Francesco Acerbi, Carlos Augusto and Petar Sucic, but also goalkeeper Josep Martinez giving Yann Sommer a rest.
Sassuolo had a rough start to the season with defeats to Napoli and Cremonese, but got themselves off the mark with a 1-0 victory against Lazio.
Yeferson Paz and Laurs Skjellerup are on the treatment table, but veteran Berardi starts in the trident attack with Armand Laurienté and former Inter youth player Andrea Pinamonti.
Nemanja Matic and ex-Milan midfielder Aster Vranckx also start for the side that won the Serie B title last season.
Inter vs. Sassuolo line-ups
Inter: J Martinez; Akanji, Acerbi, Carlos Augusto; Dumfries, Sucic, Calhanoglu, Barella, Dimarco; Thuram, Esposito
Sassuolo: Muric; Coulibaly, Idzes, Muharemovic, Doig; Vranckx, Matic, Koné; Berardi, Pinamonti, Laurienté
Player statistic
| Federico Dimarco (Assist: Petar Sucic) |
 |
14' | ||
| Hakan Calhanoglu |  |
31' |
| Federico Dimarco | |
58' | ||
| Tarik Muharemovic |  |
81' | ||
| 84' | |
Walid Cheddira (Assist: Domenico Berardi) | ||
| 90+5' | |
Tarik Muharemovic |
Match statistic
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