Paulo Dybala and Artem Dovbyk lead the way for Roma, while Manu Koné gets his first start in a tricky trip to Genoa.
It kicks off at the Stadio Luigi Ferraris, commonly known as Marassi, at 11.30 UK time (10.30 GMT).
The Giallorossi have had a difficult start to the campaign, managing only two points from three rounds and shocked by a home defeat to Empoli.
Nicola Zalewski was frozen out after rejecting a transfer to Galatasaray and Enzo Le Fée is injured.
Koné was a last-minute arrivals this summer, but after making an impressive senior debut for France this week, he gets his first start at club level too.
There is no rush for Mario Hermoso and Mats Hummels, but teenager Nicolo Pisilli is confirmed in midfield.
Genoa had a promising opening run, holding Inter 2-2 and beating Monza away, but were shaken by a 2-0 home defeat to Verona.
Junior Messias joined Fabio Miretti, Alessandro Zanoli, Brooke Norton-Cuffy, Alan Matturro and David Ankeye on the treatment table.
Morten Thorsby gets the nod behind Caleb Ekuban and Andrea Pinamonti, with Vitinha on the bench.
Genoa vs. Roma line-ups
Genoa: Gollini; Vogliacco, De Winter, Vasquez; Sabelli, Frendrup, Badelj, Thorsby, Martin; Ekuban, Pinamonti
Roma: Svilar; Mancini, N’Dicka, Angelino; Saelemaekers, Pisilli, Koné, Cristante, El Shaarawy; Dybala, Dovbyk
Player statistic
| 37' |  |
Artem Dovbyk | ||
| 45' |  |
Niccolò Pisilli |
| 65' | |
Lorenzo Pellegrini | ||
| Koni De Winter | |
70' | ||
| Koni De Winter (Assist: Vitinha) |
|
90+6' | ||
| 90+1' | |
Eldor Shomurodov |
Match statistic
