Romelu Lukaku gets his first start in the Napoli jersey and Khvicha Kvaratskhelia shakes off a knock, while Cagliari play Gianluca Gaetano against his old club.
It kicks off at the Unipol Domus stadium at 17.00 UK time (16.00 GMT).
The Partenopei had a rough start, but then won two on the bounce, even if the comeback against 10-man Parma was completed in stoppages.
Lukaku made a huge difference coming off the bench for that game and starts here with Kvaratskhelia, who has shaken off an ankle knock from international duty.
Matteo Politano is confirmed in support rather than David Neres, who has made quite an impact in his substitute appearances.
Scott McTominay and Billy Gilmour are on the bench awaiting their debuts.
Cagliari are missing Matteo Prati after his ankle sprain against Lecce, but Nadir Zortea returns and Gaetano starts against his former club.
Zito Luvumbo and Roberto Piccoli again lead the attack, with veteran Yerry Mina in defence.
Cagliari-Napoli line-ups
Cagliari: Scuffet; Zappa, Mina, Luperto; Azzi, Deiola, Marin, Gaetano, Augello; Luvumbo, Piccoli
Napoli: Meret; Di Lorenzo, Rrahmani, Buongiorno; Mazzocchi, Anguissa, Lobotka, Spinazzola; Politano, Kvaratskhelia; Lukaku
Player statistic
| 18' |  |
Giovanni Di Lorenzo (Assist: Romelu Lukaku) | ||
| 42' |  |
Stanislav Lobotka |
| 57' | |
Romelu Lukaku | ||
| 66' | |
Khvicha Kvaratskhelia (Assist: Romelu Lukaku) | ||
| 70' | |
Romelu Lukaku (Assist: Khvicha Kvaratskhelia) | ||
| Yerry Mina | |
75' | ||
| 90+3' | |
Alessandro Buongiorno (Assist: David Neres) |
Match statistic
