Inter need a result to stay clear of Napoli at the top of the table with Lautaro Martinez and Tucu Correa, but Bologna push for fourth place with Dan Ndoye.
It kicks off at the Stadio Dall’Ara at 17.00 UK time (16.00 GMT).
The Nerazzurri are still buzzing from the midweek 2-2 draw with Bayern Munich, which allowed them to set up a Champions League semi-final against Barcelona.
They are also going to face Milan in the Coppa Italia semi-final on Wednesday, so squad rotation is essential for Simone Inzaghi.
However, Marcus Thuram has an adductor issue, so is ruled out with Denzel Dumfries and Piotr Zielinski.
Marko Arnautovic is not at 100 per cent either against his old club, so Correa is chosen to partner Lautaro Martinez.
Bologna have had a great 2025 and had surged up to fourth place, but dropped down to fifth after the defeat to Atalanta.
They too are preparing for the Coppa Italia semi-final, though with a 3-0 first leg lead over Empoli, can afford to field their best XI here.
Nicolò Casale dislocated his shoulder, joining Davide Calabria, Lewis Ferguson and Lukasz Skorupski on the treatment table, while Santiago Castro is still not ready to start after a knock to his foot on international duty with Argentina.
Riccardo Orsolini is dropped for Benjamin Dominguez, with Dan Ndoye and Jens Odgaard in support.
When these teams met at San Siro in January, it was a thrilling 2-2 draw.
Bologna vs. Inter official line-ups
Bologna: Ravaglia; Holm, Beukema, Lucumì, Miranda; Freuler, Aebischer; Ndoye, Odgaard, Dominguez; Dallinga
Inter: Sommer; Pavard, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Carlos Augusto; Correa, Lautaro Martinez
Player statistic
| 39' |  |
Henrikh Mkhitaryan |
| Dan Ndoye | |
58' | ||
| 61' | |
Alessandro Bastoni | ||
| Riccardo Orsolini |  |
90+4' | ||
| Riccardo Orsolini | |
90+6' | ||
| 90' | |
Joaquín Correa |
Match statistic
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