Mateo Retegui, Ademola Lookman and Charles De Ketelaere lead Atalanta and hope to break Roma’s 20-match unbeaten streak, while Matias Soulé and Artem Dovbyk aim to leap into fourth place.
It kicks off at the Gewiss Stadium in Bergamo at 19.45 UK time (18.45 GMT, 20.45 CET).
This is a potentially crucial crossroads in the race for Champions League football, especially after the 1-1 draw between Lazio and Juventus.
A victory would let Roma leapfrog both teams to go alone into that fourth and final remaining Champions League spot, only two points behind Atalanta in third.
All to play for
La Dea go into this game off three wins in their last four games, but Isak Hien is suspended, with Juan Cuadrado, Sead Kolasinac, Marco Palestra, Gianluca Scamacca and Giorgio Scalvini injured.
Ademola Lookman is struggling with an inflamed Achilles tendon, but is still in the starting XI with De Ketelaere and Capocannoniere Retegui.
Stefan Posch and Odilon Kossounou are both recovering from long-term injuries and not at 100 per cent either, so Marten de Roon drops into the back three.
Roma are unbeaten in 20 Serie A rounds, going from just above the relegation zone when Claudio Ranieri took over to finding themselves about to go clear in fourth.
The season is over for both Lorenzo Pellegrini and Paulo Dybala, so rather than youth academy product Niccolò Pisilli in midfield, Ranieri tweaks the system.
The 3-5-2 turns into a 3-4-2-1 with Eldor Shomurodov and Soulé supporting Dovbyk, as Devyn Rensch steps into the right wing-back role.
Atalanta vs. Roma official line-ups
Atalanta: Carnesecchi; De Roon, Djimsiti, Kossounou; Bellanova, Pasalic, Ederson, Zappacosta; De Ketelaere, Retegui, Lookman
Roma: Svilar; Celik, Mancini, N’Dicka; Rensch, Cristante, Manu Koné, Angelino; Shomurodov, Soulé; Dovbyk
Player statistic
| Ademola Lookman (Assist: Charles De Ketelaere) |
 |
9' | ||
| 32' | |
Bryan Cristante (Assist: Matìas Soulé) |
| Ibrahim Sulemana | |
76' | ||
| Berat Djimsiti |  |
90' |
Match statistic
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