Napoli will be looking for their ninth straight win at home, with Victor Osimhen and Khvicha Kvaratskhelia starting against Cremonese tonight.
It kicks off at 19.45 GMT.
The Grigiorossi beat Napoli on penalties in Coppa Italia less than a month ago, but are still without victories in Serie A this term.
Luciano Spalletti can count on the whole team and the only doubt seems to be on the right flank where Hirving Lozano is favourite over Matteo Politano and Eljif Elmas.
Serie A’s Capocannoniere Osimhen and Kvaratskhelia are two obvious starters for the Partenopei. The Nigeria international netted seven goals in the last five league games.
Cremonese must cope without their starting strikers Cyriel Dessers and David Okereke.
Luka Lochoshvili, Giacomo Quagliata, Cristian Buonaiuto and Matteo Bianchetti are also not available for the hosts. Former Roma striker Felix Afena-Gyan is favourite to start over Frank Tsadjout in the Grigiorossi attack.
Marco Benassi is not fully fit, so Michele Castagnetti will get the nod in central midfield.
Afena-Gyan has scored three of his four goals as a pro in away matches, including one at the Stadio Maradona in Coppa Italia in January.
Napoli-Cremonese: probable line-ups
Napoli (4-3-3): Meret; Di Lorenz, Rrahmani, Kim, Mario Rui; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Kvaratskhelia
Cremonese (3-5-2): Carnesecchi; Ferrari, Chiriches, Vasquez; Sernicola, Castagnetti, Meite, Pickel, Valeri; Afena-Gyan, Ciofani.