Gianluca Caprari is back for Monza while Alessio Dionisi picks Gregoire Defrel to replace the injured Andrea Pinamonti.
It kicks off at 14.00 GMT.
Monza are unbeaten in the last four Serie A games and have earned 13 of their 21 points in home matches.
Giulio Donati and Filippo Ranocchia are injured, Dany Mota is not fully fit but is available.
Caprari rested against Juventus in Coppa Italia on Thursday but starts in attack today along with Patrick Ciurria and Andrea Petagna.
Sassuolo must cope without Andrea Consigli and Andrea Pinamonti. Defrel replaces the former Inter striker with Augustin Alvarez initially on the bench.
Davide Frattesi starts in the middle of the park for the Neroverdi. The Italy international has already equalled his goal record from last season, four.
Sassuolo have lost the last four games and haven’t registered a longest losing streak since 2014 when they suffered seven defeats in a row.
Monza-Sassuolo: confirmed line-ups
Monza (3-4-1-2): Di Gregorio; Marlon, Caldirola, Izzo; Birindelli, Pessina, Machin, Carlos Augusto; Ciurria; Petagna, Caprari.
Sassuolo (4-3-3): Pegolo; Toljan, Erlic, Ferrari, Rogerio; Frattesi, Obiang, Traoré; Berardi, Defrel, Laurienté.
Monza-Sassuolo: live updates