Federico Chiesa and Dusan Vlahovic are available for Juventus but are expected to start on the bench, while Alessandro Florenzi will replace the suspended Theo Hernandez for Milan.
Milan-Juventus, the big match of Serie A matchday 9 kicks off at 19:45 BST at the Stadio Meazza in Milan.
The Rossoneri are without the suspended Mike Maignan and the injured Marco Sportiello, so third-choice keeper Antonio Mirante will start in goal.
Theo Hernandez is suspended too, so Florenzi will replace him on the left flank. Rade Krunic and Pierre Kalulu are available for the Rossoneri but are not expected to start, while Ruben Loftus-Cheek is injured.
Juventus boss Massimiliano Allegri is shot of options in defence with Danilo and Alex Sandro injured. Therefore, Daniele Rugani will start at centre-back with Federico Gatti and Gleison Bremer.
Tim Weah and Weston McKennie will get the not in midfielder in a 3-5-2 formation with Arek Milik and Moise Kean in attack. Vlahovic and Chiesa are available, but are expected to be introduced from the bench in the second half.
Vlahovic has recovered from low back pain, while Chiesa trained with the team for the first time in two weeks on Friday.
Milan-Juventus: probable line-ups
Milan (4-3-3): Mirante; Calabria, Thiaw, Tomori, Florenzi; Musah, Adli, Reijnders; Pulisic, Giroud, Leao.
Juventus (3-5-2): Szczesny; Gatti, Bremer, Rugani; Weah, McKennie, Locatelli, Rabiot, Kostic; Milik, Kean.