A Milan side under the spotlight will be desperate to avoid dropping points when they host a motivated Frosinone.
The match between the Rossoneri and the Giallazzurri kicks off at 19.45 UK time at the Stadio Giuseppe Meazza in Milan.
Storm clouds have started to gather over Milanello in recent weeks, with the team winning just two of their last eight matches across Serie A and the Champions League. Their mid-week loss to Borussia Dortmund all but confirms their exit from Europe’s premier club competition.
The Rossoneri are in the midst of an injury crisis and are without Marco Sportiello, Simon Kjaer, Malick Thiaw, Pierre Kalulu, Rafael Leao, Noah Okafor and Marco Pellegrino. Ismael Bennacer is only recently returning from injury and may be left on the bench.
Frosinone have continued to look positive in their first season back in the topflight, picking up five wins and three draws in their opening 13 games.
The Giallazzurri cannot count on the injured Riccardo Marchizza, Abdou Harroui, Luca Mazzitelli, Sergio Kalaj and Pol Lirola.
Probable line-ups for Milan vs Frosinone
Milan (4-3-3): Maignan; Calabria, Tomori, Simic, Theo Hernandez; Musah, Reijnders, Loftus-Cheek; Chukwueze, Jovic, Pulisic.
Frosinone (4-2-3-1): Turati; Oyono, Okoli, Romagnoli, Monterisi; Mazzitelli, Barrenechea; Soulé, Ibrahimovic, Reinier; Cheddira.