We begin at 11.30 UK time (10.30 GMT) at the Stadio Castellani, where deeply unpredictable Empoli host Sampdoria. You can follow the live updates from the Castellani here.
At 14.00 UK time (13.00 GMT), there’s a relegation tussle between Venezia and Spezia, with the Lagunari finally able to play at their restructured Stadio Penzo, the only stadium you have to reach by boat. Follow the live coverage for the game here.
Meanwhile, Lazio try to put their recent setbacks behind them against another side under new management, as Walter Mazzarri arrives at Cagliari.
All eyes are on the Allianz Juventus Stadium in Turin at 19.45 UK time (18.45 GMT), for a huge battle between giants Juventus and Milan.
The Bianconeri have just one point from three rounds and desperately need to turn things around against one of the only sides with a perfect Serie A record so far.