Jose Mourinho radically transforms his Roma side in the trip to Venezia, adopting a 3-4-1-2 formation with Lorenzo Pellegrini behind Tammy Abraham and Eldor Shomurodov.
It kicks off at the Stadio Penzo at 11.30 GMT.
The Giallorossi have been stuttering for weeks now, with the 6-1 defeat to Bodo/Glimt sparking a crisis of form and confidence.
They were held 2-2 by the same Norwegian side on Thursday in the Europa Conference League, showing more signs of difficulty.
Matias Vina, Riccardo Calafiori, Leonardo Spinazzola and Chris Smalling are all injured, so this leaves no genuine left-backs.
Rather than again use Roger Ibanez there, Mourinho has radically changed his tactics from a 4-2-3-1 to a 3-4-1-2, moving Stephan El Shaarawy and Rick Karsdorp to wing-backs, with Lorenzo Pellegrini playing on despite a knee problem.
He supports Abraham and Eldor Shomurodov upfront.
Venezia have Ethan Ampadu back after his ban for an inexplicable red card, but Dennis Johnsen and Antonio Junior Vacca are still out of action.
David Okereke leads the attack with Sofiane Kiyine, while Gianluca Busio is in midfield.
Venezia: Romero; Mazzocchi, Caldara, Ceccaroni, Haps; Crnigoj, Busio, Ampadu; Aramu, Okereke, Kiyine
Roma: Rui Patricio; Mancini, Kumbulla, Ibanez; Karsdorp, Cristante, Veretout, El Shaarawy; Pellegrini; Abraham, Shomurodov