Victor Osimhen returns to the starting XI for the first time since November 21 as Napoli visit a revamped Venezia with a chance to close within a point of leaders Inter.
It kicks off at the Stadio Luigi Penzo at 14.00 GMT.
Liveblog: Serie A inc Atalanta-Cagliari, Venezia-Napoli, Juventus-Verona
Last night’s Derby Della Madonnina result means Napoli can close to within a point of Inter and stick with Milan in second place, even if the Nerazzurri still have a game in hand.
Osimhen is back in the starting line-up for the first time since the devastating clash of heads with Inter defender Milan Skriniar on November 21, which left him with multiple facial fractures requiring six metal plaques and 18 screws.
He has a new, more streamlined protective mask and leads the way with support from Matteo Politano, Piotr Zielinski and Lorenzo Insigne.
Kalidou Koulibaly and Zambo Anguissa are at the Africa Cup of Nations, with Hirving Lozano, Axel Tuanzebe and Adam Ounas injured.
Venezia were very active in the January transfer window, but also had a massive COVID outbreak, so while many players are now negative, they’re still lacking match fitness.
Antonio Vacca Junior, Sofian Kiyine and Ullmann are on the treatment table.
Venezia will wear black armbands in honour of former President Maurizio Zamparini, who died this week.
Venezia: Lezzerini; Ebuehi, Caldara, Ceccaroni, Haps; Crnigoj, Ampadu, Cuisance; Nani, Okereke, Johnsen
Napoli: Ospina; Di Lorenzo, Rrahmani, Juan Jesus, Mario Rui; Lobotka, Fabian Ruiz; Politano, Zielinski, Insigne; Osimhen