Milan are again down to the bare bones, but start Zlatan Ibrahimovic and Rafael Leao upfront against high-flying Venezia, who debut ex-Bayern Munich midfielder Michael Cuisance.
It kicks off at the Stadio Penzo at 11.30 GMT, you can follow the build-up and action as it happens from today’s eight Serie A games on the LIVEBLOG.
The Rossoneri started 2022 on the right foot with a 3-1 victory over Roma, despite missing 11 players through COVID, injuries and Africa Cup of Nations duty.
The situation remains the same here, without Davide Calabria, Fikayo Tomori, Alessio Romagnoli, Samu Castillejo, Ciprian Tatarusanu, Pietro Pellegri, Simon Kjaer, Fode Ballo-Toure, Franck Kessie and Ismael Bennacer.
Stefano Pioli does make changes, bringing in Ibrahimovic, Leao and Tiemoue Bakayoko.
Venezia have their first game of 2022, because the previous fixture was cancelled due to a COVID outbreak at Salernitana.
Mattia Caldara is suspended against his former club, along with Tanner Tessmann, while Tyronne Ebuehi is on international duty.
David Okereke leads the attack with support from Mattia Aramu and Thomas Henry, but Michael Cuisance is thrown straight in for his debut after the transfer from Bayern Munich.
Venezia: Romero; Mazzocchi, Svoboda, Ceccaroni, Haps; Cuisance, Ampadu, Busio; Aramu, Henry, Okereke
Milan: Maignan; Florenzi, Kalulu, Gabbia, Theo Hernandez; Tonali, Bakayoko; Saelemaekers, Brahim Diaz, Leao; Ibrahimovic