It kicks off at the Stadio Penzo at 19.45 GMT, the only stadium in Italy that has to be reached by boat.
The Nerazzurri have found their form in Serie A and Europe, beating leaders Napoli to close the gap at the top of the table and securing their place in the Champions League Round of 16.
With the midweek round coming up, Simone Inzaghi rotates the squad with Alexis Sanchez, Arturo Vidal, Stefan de Vrij and Aleksandar Kolarov injured.
He brings Tucu Correa into the starting XI with Edin Dzeko, while there are surprises in defence, Alessandro Bastoni flanked by Milan Skriniar and Federico Dimarco.
🛥️ | DOCKING
— Inter 🏆🇮🇹 (@Inter_en) November 27, 2021
Tyronne Ebuehi and Niki Maenpaa are new additions to the injury list.
Ethan Ampadu, Gianluca Busio and Antonio Junior Vacca form the midfield, with David Okereke leading the line.
Venezia: Romero; Mazzocchi, Caldara, Ceccaroni, Haps; Ampadu, Vacca, Busio; Aramu, Kiyine; Okereke
Inter: Handanovic; Skriniar, Bastoni, Dimarco; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Correa