Lazio desperately need to get back on track after a series of faltering results and make big changes for this trip to injury-hit Torino.
It kicks off at the Stadio Olimpico Grande Torino at 17.30 UK time (16.30 GMT).
The Biancocelesti had started strong under Maurizio Sarri, but have rather lost their way recently with defeats to Milan and Galatasaray, then a 2-2 home draw with struggling Cagliari.
The Rome Derby is coming up on Sunday, so confidence needs to be boosted quickly, but Mattia Zaccagni is ruled out by injury.
This is when Sarri opts to rotate his squad, benching Pedro, Sergej Milinkovic-Savic and Lucas Leiva, keeping only Ciro Immobile and Felipe Anderson upfront with youngster Raul Moro.
Torino are finding their feet under new boss Ivan Juric, even though Andrea Belotti, Armando Izzo, Dennis Praet and Simone Zaza are still out of action.
Marko Pjaca scored the late winner against Sassuolo last week, but he too is not 100 per cent fit due to a muscular issue.
Karol Linetty therefore steps in with Josip Brekalo and Antonio Sanabria.
Curiously, this will be a battle of the Milinkovic-Savic brothers, Vanja in goal for Torino and older sibling Sergej in midfield for Lazio.
Torino: V Milinkovic-Savic; Djidji, Bremer, Rodriguez; Singo, Pobega, Mandragora, Aina; Linetty, Brekalo; Sanabria
Lazio: Reina; Marusic, Luiz Felipe, Acerbi, Hysaj; Akpa-Akpro, Cataldi, Luis Alberto; Felipe Anderson, Immobile, Moro