Both Spezia and Sampdoria are struggling so far this season and in dire need of a victory as they go head-to-head.
It kicks off at the Stadio Alberto Picco at 17.00 UK time (16.00 GMT).
The hosts won their opening fixture against Empoli, but since then managed only two stalemates from five rounds, losing narrowly to Napoli last time out.
Daniele Verde, Kelvin Amian, Daniel Maldini and Salva Ferrer are still on the treatment table, but Albin Ekdal returns to the fold after suspension.
Sampdoria are without coach Marco Giampaolo, who begins a two-match touchline ban for insulting the referee during the defeat to 10-man Milan.
Harry Winks, Simone Trimboli and Manuel De Luca remain out of action.
Spezia: Dragowski; Ampadu, Kiwior, Nikolaou; Holm, Kovalenko, Bourabia, Bastoni, Reca; Gyasi, Nzola
Sampdoria: Audero; Bereszynski, Ferrari, Murillo, Augello; Villar; Leris, Rincon, Sabiri, Djuricic; Caputo