Milan have Olivier Giroud back in the starting XI with Daniel Maldini, but injuries are beginning to pile up elsewhere, as they visit a Spezia side who very nearly shocked Juventus midweek.
It kicks off at the Stadio Picco at 14.00 UK time (13.00 GMT).
The Rossoneri are unbeaten in Serie A so far this season and dropped points only once, in a 1-1 draw in Turin, so confidence is high.
Giroud returns after an injury lay-off, but Zlatan Ibrahimovic, Simon Kjaer, Rade Krunic and Tiemoue Bakayoko are still out of action.
They are joined on the treatment table by Alessandro Florenzi, although Davide Calabria is available again on the bench.
In order to rest Brahim Diaz, there’s a first Serie A start for Daniel Maldini, the son of Paolo and grandson of Cesare.
Spezia had been 2-1 up against Juventus before capitulating 3-2 and are starting to find their feet under coach Thiago Motta.
His options remain limited, as Kevin Agudelo, Ebrima Colley, Martin Erlic, Leo Sena, Victor Kovalenko and Arkadiusz Reca are still out of action.
M’Bala Nzola steps into the centre-forward role.
Spezia: Zoet; Amian, Nikolaou, Hristov, S Bastoni; Bourabia, Sala; Antiste, Maggiore, Gyasi; Nzola
Milan: Maignan; Kalulu, Tomori, A Romagnoli, Theo Hernandez; Tonali, Kessie; Saelemaekers, Maldini, Rebic; Giroud