Juventus bring in Moise Kean and Federico Chiesa with Paulo Dybala in their must-win trip to Spezia.
It kicks off at 17.30 UK time (16.30 GMT).
The Bianconeri have had a dismal start to the campaign, with just two points from four rounds, and fumbled seven points from leading situations.
This will feel like a must-win game, yet Spezia are fresh from their first win of the season, a last-gasp 2-1 victory over Sassuolo.
Giorgio Chiellini drops out of the side, with Arthur and Kaio Jorge, while Alvaro Morata has a slight muscular issue.
Kean therefore starts with Dybala upfront, supported by Chiesa and Weston McKennie.
Spezia are missing Martin Erlic, Kevin Agudelo, Ebrima Colley, Viktor Kovalenko, Arkadiusz Reca and Leo Sena.
Mehdi Bourabia scored the winner against Sassuolo and earns a spot in the starting XI with Daniele Verde and Janis Antiste.
Spezia: Zoet; Amian, Nikolaou, Hristov, S Bastoni; Ferrer, Bourabia; Verde, Maggiore, Gyasi; Antiste
Juventus: Szczesny; Danilo, De Ligt, Bonucci, De Sciglio; McKennie, Bentancur, Rabiot, Chiesa; Dybala, Kean