Giacomo Raspadori starts for Sassuolo against Torino, while Ivan Juric looks to Antonio Sanabria and Josip Brekalo.
It kicks off at 19.45 UK time at the Mapei Stadium.
Sassuolo collected four points in three games, while Torino won their first game last week, beating Salernitana 4-0 at home.
They lost the first two games against Atalanta and Fiorentina.
Andrea Belotti is out of action with a severely bruised fibula, so Sanabria replaces him up front.
The Paraguay striker opened the scoring against Salernitana last weekend.
Giacomo Raspadori starts for the Neroverdi with Gianluca Scamacca on the bench.
Inter have been linked with both Sassuolo strikers and according to reports in Italy, the Nerazzurri will scout Raspadori and Scamacca tonight, provided the latter comes off the bench at some point.
Inter will also scout Gleison Bremer, who starts at centre-back for the Granata.
Sassuolo vs. Torino line-ups
Sassuolo: Consigli; Toljan, Chiriches, Ferrari, Rogerio; Frattesi, Lopez; Berardi, Djuricic, Boga; Raspadori
Torino: Milinkovic; Djidji, Bremer, Rodriguez; Singo, Pobega, Lukic, Aina; Praet, Brekalo; Sanabria