Lazio are forced to completely revamp their midfield in this trip to giant-killers Sassuolo, as Gianluca Scamacca and Domenico Berardi face Ciro Immobile.
It kicks off at the Mapei Stadium at 17.00 GMT, you can follow all the build-up and action as it happens from today’s five Serie A games on the LIVEBLOG.
The Neroverdi have made a habit of upsetting the top teams, beating Milan and Juventus, while holding Napoli to a 2-2 draw.
Scamacca has found form lately and has a point to prove against his competition for the Italy centre-forward role, Ciro Immobile.
He is supported by Domenico Berardi and Giacomo Raspadori, as Filip Djuricic and Pedro Obiang are injured.
Lazio were held 0-0 by Galatasaray in the Europa League on Thursday, meaning they will face a play-off in February.
Sergej Milinkovic-Savic is suspended following his red card for dissent against Sampdoria, while Luis Alberto is carrying an injury.
Maurizio Sarri therefore has to reshuffle his midfield with Toma Basic, Danilo Cataldi and Jean-Daniel Akpa-Akpro.
Sassuolo: Consigli; Toljan, Chiriches, Ferrari, Rogerio; Frattesi, Lopez, Traore; Berardi, Scamacca, Raspadori
Lazio: Strakosha; Hysaj, Luiz Felipe, Acerbi, Marusic; Akpa-Akpro, Cataldi, Basic; Pedro, Immobile, Zaccagni
Omg Akpa Akpro! I have a bad feeling about this…