Inter start Lautaro Martinez, Joaquin Correa and Denzel Dumfries for this trip to Sassuolo, with Gregoire Defrel supported by Domenico Berardi and Jeremie Boga.
It kicks off at the Mapei Stadium at 19.45 UK time (18.45 GMT).
The Nerazzurri are unbeaten in Serie A, but coming off a pair of stalemates against Atalanta and Champions League opponents Shakhtar Donetsk.
Stefano Sensi and Christian Eriksen are the only absentees, so Simone Inzaghi picks Dumfries and Ivan Perisic on the wings, supporting Lautaro Martinez and Correa.
Sassuolo ended their run of three consecutive defeats with a 1-0 scraped victory over Salernitana.
Pedro Obiang and Filippo Romagna are long-term injury cases, but Berardi, Filip Djuricic and Boga support striker Defrel, benching Giacomo Raspadori, who is named in the Italy squad for the Nations League games.
There were some concerns for goalkeeper Andrea Consigli, who trained separately over the last few days, but he is in the starting XI.
Sassuolo: Consigli; Muldur, Chiriches, Ferrari, Rogerio; Lopez, Frattesi; Berardi, Djuricic, Boga; Defrel
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Lautaro Martinez, Correa