With Nicolò Zaniolo injured, Roma stick with the same XI that won the derby, including Tammy Abraham and Lorenzo Pellegrini, against Stefano Sensi’s Sampdoria.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 17.00 UK time (16.00 GMT).
The Giallorossi are brimming with confidence after crushing rivals Lazio 3-0 to leap into fifth place.
Zaniolo was left on the bench in that game and picked up an injury playing for Italy, so joins Leonardo Spinazzola and Jordan Veretout on the absentee list.
Abraham is supported by Lorenzo Pellegrini and Henrikh Mkhitaryan, with Nicola Zalewski on the left wing.
Sampdoria miss Sebastian Giovinco, Manolo Gabbiadini and Mikkel Damsgaard, with Albin Ekdal not fully fit either.
Sensi and Antonio Candreva pull the midfield strings, with Abdelhamid Sabiri supporting Francesco Caputo.
Sampdoria: Audero; Bereszynski, Ferrari, Colley, Murru; Candreva, Rincon, Thorsby; Sensi; Sabiri, Caputo
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Oliveira, Zalewski; Mkhitaryan, Pellegrini; Abraham