Hirving Lozano joins Lorenzo Insigne and Victor Osimhen upfront, as Napoli try to maintain their 100 per cent record against Fabio Quagliarella’s Sampdoria.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 17.30 UK time (16.30 GMT).
The Partenopei are the only side with a perfect record after four rounds and a victory here would keep them top of the table.
Diego Demme, Dries Mertens, Stanislav Lobotka and Faouzi Ghoulam are still out of action, while Amir Rrahmani is again preferred to Kostas Manolas.
Luciano Spalletti opts for a 4-3-3 formation with Lozano, Insigne and Osimhen upfront.
Sampdoria are fresh from a victory away to Empoli, although Manolo Gabbiadini, Valerio Verre and Ronaldo Vieira are still injured.
Morten Thorsby had a slight muscular issue, but he is in the starting XI with Adrien Silva, while Quagliarella and Ciccio Caputo form a veteran strike partnership.
Sampdoria: Audero; Bereszynski, Yoshida, Colley, Augello; Candreva, Thorsby, Adrien Silva, Damsgaard; Caputo, Quagliarella
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Anguissa, Fabian Ruiz, Zielinski; Lozano, Osimhen, Insigne