Both Lazio and Sampdoria want to get back on track after disappointing results, as Maurizio Sarri drops Pepe Reina and Luis Alberto to the bench.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 17.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Aquile have just one point from the last three rounds, losing to Juventus and Napoli heavily before a dramatic 4-4 draw with Udinese midweek.
Luiz Felipe returns from suspension, but is replaced in the stands by Patric, while Sarri sends Luis Alberto to the bench in favour of Toma Basic.
Ciro Immobile, Pedro and Mattia Zaccagni lead the attack, with Felipe Anderson also dropped following a slew of poor performances.
Even goalkeeper Pepe Reina is dumped for Thomas Strakosha’s first Serie A start of the season.
Sampdoria had boosted their prospects with back-to-back wins over Salernitana and Verona, but were beaten 3-1 by Fiorentina midweek and coach Roberto D’Aversa is again under pressure.
Omar Colley sits out a ban in defence, with Mikkel Damsgaard, Fabio Depaoli and Ernesto Torregrossa injured.
Sampdoria: Audero; Bereszynski, Ferrari, Chabot, Augello; Candreva, Thorsby, Ekdal, Verre; Quagliarella, Gabbiadini
Lazio: Strakosha; Hysaj, Luiz Felipe, Acerbi, Marusic; Milinkovic-Savic, Cataldi, Basic; Pedro, Immobile, Zaccagni