Inter rely on Edin Dzeko, Lautaro Martinez and Hakan Calhanoglu for this trip to Sampdoria, who give Francesco Caputo his debut alongside Fabio Quagliarella.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 11.30 UK time (10.30 GMT).
The Nerazzurri have had a perfect start to the campaign under new coach Simone Inzaghi, despite losing star names like Romelu Lukaku and Achraf Hakimi.
Despite returning late from international duty in Argentina, Lautaro Martinez is still in the starting XI with Edin Dzeko.
Calhanoglu and Marcelo Brozovic can also provide the midfield creativity.
Alessandro Bastoni is injured, so Federico Dimarco steps into the back three.
Samp have not scored yet this season, so signed Caputo from Sassuolo on deadline day, and he makes his debut here alongside veteran Quagliarella.
Manolo Gabbiadini, Ernesto Torregrossa, Albin Ekdal and Nicola Murru are out of action.
Sampdoria: Audero; Bereszynski, Yoshida, Colley, Augello; Candreva, Silva, Thorsby, Damsgaard; Caputo, Quagliarella
Inter: Handanovic; Skriniar, De Vrij, Dimarco; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Lautaro Martinez