It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 11.30 UK time (10.30 GMT).
Despite returning late from international duty in Argentina, Lautaro Martinez is still in the starting XI with Edin Dzeko.
Calhanoglu and Marcelo Brozovic can also provide the midfield creativity.
Samp have not scored yet this season, so signed Caputo from Sassuolo on deadline day, and he makes his debut here alongside veteran Quagliarella.
Sampdoria: Audero; Bereszynski, Yoshida, Colley, Augello; Candreva, Silva, Thorsby, Damsgaard; Caputo, Quagliarella
Inter: Handanovic; Skriniar, De Vrij, Dimarco; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Lautaro Martinez