Atalanta have not started their season well and look to Ruslan Malinovskyi and Aleksei Miranchuk, while Franck Ribery tries to reboot Salernitana’s fortunes.
It kicks off at the Stadio Arechi at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
La Dea have stuttered this term, as they often do under Gian Piero Gasperini in the early weeks of a season, a situation made worse by the serious injury to Luis Muriel and Hans Hateboer.
Marten de Roon is also suspended, so Duvan Zapata has to start upfront with support from Ruslan Malinovskyi and Aleksei Miranchuk.
Salernitana have lost all three matches this season, including back-to-back 4-0 results against Roma and Torino, fuelling reports coach Fabrizio Castori could already be axed.
He needs to show some reaction here, and throws Ribery in from the start after a brief substitute appearance last week.
This also means a change of tactics to give the Frenchman a role behind the two strikers, who surprisingly are not Nwankwo Simy and Federico Bonazzoli, but rather Milan Djuric and Cedric Gondo.
Lassana and Mamadou Coulibaly – no relation – start together in midfield, but Ivan Ruggeri, Leonardo Capezzi and Frederic Veseli are not fully fit.
Salernitana: Belec; Gyomber, Strandberg, Gagliolo; Kechrida, M Coulibaly, L Coulibaly, Ranieri; Ribery; Djuric, Gondo
Atalanta: Musso; Toloi, Demiral, Palomino; Maehle, Freuler, Malinovskyi, Gosens; Pasalic, Duvan Zapata, Miranchuk
Ref: Valeri