Roma and Udinese are both coming off their first defeats of the season, as Henrikh Mkhitaryan returns to the XI with Tammy Abraham.
It kicks off at 19.45 UK time (18.45 GMT) at the Stadio Olimpico.
The Giallorossi had a perfect record after six games between Serie A and the Conference League, but suffered a shock 3-2 defeat to Hellas Verona.
Matias Vina is still not fully fit, so Riccardo Calafiori is again at left-back, with Leonardo Spinazzola out for several more months.
Mkhitaryan returns to the starting XI with Abraham, Lorenzo Pellegrini and Nicolò Zaniolo.
Udinese also lost their first match last week, 4-0 to Napoli, but had until now been doing surprisingly well.
Ilija Nestorovski is still out of action, while Jens Stryger-Larsen is only on the bench after a late fitness test, but Destiny Udogie does return.
Roma: Rui Patricio; Karsdorp, Mancini, Ibanez, Calafiori; Cristante, Veretout; Zaniolo, Pellegrini, Mkhitaryan; Abraham
Udinese: Silvestri; Becao, Nuytinck, Samir; Molina, Pereyra, Walace, Makengo, Udogie; Pussetto, Deulofeu