Jose Mourinho has picked Borja Mayoral and Tammy Abraham up front when Roma and Spezia conclude Serie A Week 17 on Monday night.
The match at the Olimpico kicks off at 19.45 UK time.
The official line-ups of Mourinho and Thiago Motta have arrived and the Giallorossi need a win to catch up with Juventus and get closer to Fiorentina.
The Ligurians, however, are looking for points to break away from Genoa and Cagliari at the other end of the table.
Borja Mayoral will join Abraham in attack, as Mourinho continues with a 3-5-2 formation, with Marash Kumbulla, Chris Smalling and Roger Ibanez at the back.
Rick Karsdorp returns to the right after the suspension.
Line-ups: Roma vs. Spezia
Roma (3-5-2): Rui Patricio; Smalling, Kumbulla, Ibanez; Karsdorp, Cristante, Veretout, Mkhitaryan, Vina; Mayoral, Abraham
Spezia (3-5-2): Provedel; Amian, Erlic, Nikolaou; Gyasi, Maggiore, Sala, Kovalenko; Reca; Strelec, Manaj