Roma aim to create some momentum with Tammy Abraham and Nicolò Zaniolo against Manolo Gabbiadini’s Sampdoria.
It kicks off at 17.30 GMT, you can follow all the build-up and action as it happens from today’s seven Serie A games on the LIVEBLOG.
The Giallorossi are fresh from a 4-1 win away to Atalanta and need a victory to keep up with fifth-placed Juventus.
The absentee list is finally getting shorter for Jose Mourinho, as only Stephan El Shaarawy, Lorenzo Pellegrini and Leonardo Spinazzola are out of action.
Felix Afena-Gyan also returns from suspension, but Zaniolo and Abraham continue to work on their rapport upfront, with Chris Smalling helping to solidify the defence.
Samp are without goalkeeper Emil Audero due to a muscular problem he sustained in the 1-1 draw with Venezia, so Wladimiro Falcone gets a rare start.
Manolo Gabbiadini has shaken off a knock to start, with Valerio Verre and Mikkel Damsgaard ruled out.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Veretout, Cristante, Mkhitaryan, Vina; Zaniolo, Abraham
Sampdoria: Falcone; Bereszynski, Yoshida, Colley, Augello; Candreva, Silva, Ekdal, Askildsen; Caputo, Gabbiadini