Roma are in crisis after their Norwegian humiliation, but have Nicolò Zaniolo back with Tammy Abraham against leaders Napoli’s Victor Osimhen and Lorenzo Insigne.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
The Giallorossi are in the toughest week of Jose Mourinho’s tenure so far, losing 1-0 away to Juventus, then on Thursday embarrassed 6-1 in the Conference League by Bodo/Glimt.
Mou said afterwards that he only had 13 players in the squad, the others were not anywhere near the same level, and he’s doubling down on that condemnation of his own team.
Several relatively big names are sent to the stands today, as he picks the same XI that lost to Juventus last week, with the return of Zaniolo from injury.
Leonardo Spinazzola and Chris Smalling are still out of action.
Mou sends Borja Mayoral, Gonzalo Villar, Marash Kumbulla, Amadou Diawara and Bryan Reynolds to the stands as punishment for the Norwegian debacle.
Napoli have a 100 per cent Serie A record this season with eight wins out of eight, and are fresh from Thursday’s Europa League victory over Legia Warsaw.
Osimhen again leads the attack with Insigne and Matteo Politano, while Piotr Zielinski has recovered in midfield.
Kostas Manolas joins Kevin Malcuit and Adam Ounas on the sidelines.
Roma: Rui Patricio; Karsdorp, Mancini, Ibanez, Vina; Cristante, Veretout; Zaniolo, Pellegrini, Mkhitaryan; Abraham
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Anguissa, Fabian Ruiz, Zielinski; Politano, Osimhen, Insigne