Roma start the same XI yet again, while Milan get Theo Hernandez and Zlatan Ibrahimovic back, but Brahim Diaz is on the bench.
It kicks off at the Stadio Olimpico at 19.45 GMT.
Jose Mourinho continues to freeze out Borja Mayoral, Gonzalo Villar, Amadou Diawara and Bryan Reynolds, leaving them in the stands after the 6-1 Conference League defeat to Bodo/Glimt.
He had used the same starting XI for the last couple of matches against Napoli and Cagliari, and had been expected to bring Stephan El Shaarawy in for Henrikh Mkhitaryan, but he sticks with the usual line-up.
The Armenian starts with Lorenzo Pellegrini, Nicolò Zaniolo and Tammy Abraham.
This is also a special game for former Chelsea teammates and close friends Abraham and Fikayo Tomori.
Milan need a victory to stay top of the Serie A table and the injury crisis is beginning to calm down a little for coach Stefano Pioli.
Ante Rebic, Samu Castillejo, Mike Maignan, Ballo-Toure, Alessandro Florenzi, Junior Messias and Pietro Pellegri are out of action.
However, Brahim Diaz and Theo Hernandez have recovered from COVID-19, with the Spaniard on the bench.
Ibrahimovic gets the nod upfront rather than Olivier Giroud at the Stadio Olimpico.
Roma: Rui Patricio; Karsdorp, Mancini, Ibanez, Vina; Cristante, Veretout; Zaniolo, Pellegrini, Mkhitaryan; Abraham
Milan: Tatarusanu; Calabria, Kjaer, Tomori, Theo Hernandez; Bennacer, Kessie; Saelemaekers, Krunic, Leao; Ibrahimovic