It is a day of reunions at the Stadio Olimpico, as Jose Mourinho and Edin Dzeko face their past and a decimated Roma host on-form title-holders Inter.
It kicks off in the Capital at 17.00 GMT.
Serie A Liveblog: Milan-Salernitana, Roma-Inter, Napoli-Atalanta
The Nerazzurri have blown the Scudetto race with open with a run of victories and are aiming for another big scalp to create an even bigger gap between the top four and the chasing pack.
Mourinho faces his former club as a Serie A rival for the first time since winning the Treble in 2010, but he’s still fuming after the 1-0 defeat to Bologna.
Tammy Abraham and Rick Karsdorp were booked, meaning they are suspended for this game, with Stephan El Shaarawy, Lorenzo Pellegrini and Leonardo Spinazzola injured.
Add in Felix Afena-Gyan with COVID-19 and there are precious few options.
Matias Vina returns to the starting XI after a long lay-off, while Gonzalo Villar and Bryan Cristante have recovered from COVID-19.
Nicolò Zaniolo also has a point to prove, as Roma bought him from Inter as part of the deal for Radja Nainggolan, and he partners Eldor Shomurodov in a 3-5-2 formation.
Inter have issues in defence, missing Stefan de Vrij, Andrea Ranocchia, Mattia Darmian and Aleksandar Kolarov, but Alessandro Bastoni is back.
It’s a big game for Dzeko, who spent six years in the Giallorossi jersey, and he is partnered by Joaquin Correa, who caused Roma so many problems playing for Lazio.
Roma: Rui Patricio; Smalling, Mancini, Kumbulla; Ibanez, Veretout, Cristante, Mkhitaryan, Vina; Zaniolo, Shomurodov
Inter: Handanovic; D’Ambrosio, Skriniar, Bastoni; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Correa