Roma aim to get back on track in Serie A after the derby defeat, as Lorenzo Pellegrini returns from suspension against giant-killers Empoli.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
Jose Mourinho is still smarting after the 3-2 Derby della Capitale defeat to Lazio, although Thursday’s 3-0 Europa Conference League victory away to Zorya Luhask was some scant consolation.
Pellegrini was suspended for the derby after a controversial red card against Udinese, but he returns here, having signed a new contract to June 2026.
Tammy Abraham, Henrikh Mkhitaryan and Nicolò Zaniolo complete the forward line, with Ebrima Darboe rewarded in midfield after a fine performance midweek.
Empoli are an all or nothing team, capable of beating Juventus in Turin or losing at home to Venezia.
Lorenzo Tonelli and Riccardo Fiamozzi return to the bench, but Federico Di Francesco and Andrea Pinamonti lead the attack rather than Patrick Cutrone.
Roma: Rui Patricio; Karsdorp, Mancini, Smalling, Vina; Darboe, Veretout; Zaniolo, Pellegrini, Mkhitaryan; Abraham
Empoli: Vicario; Stojanovic, Romagnoli, Viti, Marchizza; Ricci, Henderson, Zurkowski, Bandinelli; Di Francesco, Pinamonti