Dries Mertens leads the attack with Mario Rui returning for Napoli against troubled Spezia, but Lorenzo Insigne has COVID-19.
It kicks off at 19.45 GMT, you can follow all the build-up and action as it happens from today’s seven Serie A games on the LIVEBLOG.
The Partenopei are feeling confident after their 1-0 win away to Milan, which allowed them to join the Rossoneri in joint second place.
Insigne missed that game with an injury and is now out after testing positive for COVID-19.
Victor Osimhen, Kalidou Koulibaly and Fabian Ruiz are still out of action, but Mario Rui is back in the starting XI.
Andrea Petagna was the surprise pick against Milan to lead the line, though Mertens returns here.
Spezia are in dire condition and there are reports coach Thiago Motta hasn’t been sacked yet because a clause would force the club to pay extra if he was dismissed before January 1.
Daniele Verde, Jacopo Sala and Eddie Salcedo are carrying knocks, while striker M’Bala Nzola has a stomach bug.
Napoli: Ospina; Di Lorenzo, Rrahmani, Juan Jesus, Mario Rui; Anguissa, Lobotka; Politano, Zielinski, Lozano; Mertens
Spezia: Provedel; Amian, Erlic, Nikolaou; Gyasi, Maggiore, Kiwior, Bastoni, Reca; Manaj, Agudelo