Napoli’s absentee list continues to grow, as Piotr Zielinski is also out, while Lorenzo Insigne and Dries Mertens lead the way against a Sampdoria side missing Antonio Candreva.
It kicks off at 15.30 GMT at the Stadio Diego Armando Maradona.
The situation has deteriorated at Napoli after the 1-1 draw with Juventus, as Piotr Zielinski has also now tested positive for COVID-19, after Victor Osimhen, Hirving Lozano, Alex Meret and Mario Rui, while Fabian Ruiz is back in the squad.
Kalidou Koulibaly, Andre Frank Zambo Anguissa and Adam Ounas are at the Africa Cup of Nations.
The good news is Luciano Spalletti is back on the touchline after testing negative this morning.
Eljif Elmas steps in for Zielinski with Mertens and new Toronto FC signing Insigne, supporting Andrea Petagna.
Sampdoria are coming off a shock home defeat to Cagliari and have Candreva suspended following his red card.
Mikkel Damsgaard, Maya Yoshida, Valerio Verre and Omar Colley are out of action too.
Manolo Gabbiadini faces his former club and has scored in each of his last six Serie A appearances.
Napoli: Ospina; Di Lorenzo, Rrahmani, Juan Jesus, Ghoulam; Demme, Lobotka; Elmas, Mertens, Insigne; Petagna
Sampdoria: Audero; Dragusin, Ferrari, Chabot, Augello; Ciervo, Ekdal, Askildsen, Thorsby; Gabbiadini, Quagliarella