Napoli start Dries Mertens, with Victor Osimhen and Lorenzo Insigne on the bench as they face Salernitana in a local derby.
It kicks off at the Stadio Diego Armando Maradona at 14.00 GMT.
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The Partenopei crashed out of the Coppa Italia, so the focus is all on getting their Serie A campaign back on track.
Luciano Spalletti is starting to get some options back, but Osimhen does not get his first start since suffering multiple facial fractures during a clash of heads against Inter two months ago.
Instead, Mertens leads the way with support from Hirving Lozano, Piotr Zielinski and Eljif Elmas.
Lorenzo Insigne and David Ospina are back on the bench after injury, though Kalidou Koulibaly, Andre-Frank Zambo Anguissa and Adam Ounas are still unavailable.
Napoli are playing in yet another new kit design.
Salernitana almost had the game cancelled after a COVID outbreak in the squad, but some have since tested negative and they do not reach the threshold of nine players simultaneously out.
They’re still down to the bare bones in this Derby di Campania.
Napoli: Meret; Di Lorenzo, Rrahmani, Juan Jesus, Mario Rui; Lobotka, Fabian Ruiz; Elmas, Zielinski, Lozano; Mertens
Salernitana: Belec; Veseli, Bogdan, Gagliolo; Delli Carri, Schiavone, Di Tacchio, Obi, Kechrida; Vergani, Bonazzoli