Dries Mertens and Lorenzo Insigne lead Napoli out as they get used to life without Victor Osimhen, while Maurizio Sarri’s Lazio rely on Ciro Immobile and Sergej Milinkovic-Savic on a night dedicated to Diego Maradona.
It kicks off at the Stadio Diego Armando Maradona at 19.45 GMT.
This is a very special night in Naples, as a year on from Maradona’s death, a life-size statue of the icon will be presented to the fans.
It’ll be paraded around the pitch before it is given a permanent home just outside the stadium.
Napoli had a tough week, losing to Inter in Serie A and Spartak Moscow in the Europa League, but a result here will put them clear at the top of the table.
Osimhen was ruled out for three months after suffering multiple facial fractures in a clash of heads with Inter defender Milan Skriniar.
Matteo Politano still has COVID-19, though Diego Demme has recovered, with Andre Frank Zambo Anguissa and Adam Ounas injured.
Mertens was transformed into a centre-forward by Sarri and he retakes that role here tonight, with support from Lorenzo Insigne and Piotr Zielinski.
Lazio have a full squad at their disposal other than Adam Marusic, who is still positive for COVID-19.
Once again, Patric is chosen at right-back rather than Manuel Lazzari.
Immobile made his comeback midweek in the Europa League and scored two goals, but this is always a special game for the native Neapolitan.
Sarri was a hero at Napoli and came close to the Scudetto, but was somewhat disowned by fans after joining Chelsea and then Juventus.
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Lobotka, Fabian Ruiz; Lozano, Zielinski, Insigne; Mertens
Lazio: Reina; Patric, Luiz Felipe, Acerbi, Hysaj; Milinkovic-Savic, Cataldi, Luis Alberto; Felipe Anderson, Immobile, Pedro