Napoli look to Dries Mertens and Adam Ounas against impressive Empoli, as a win would temporarily put them top of the table.
It kicks off at the Stadio Diego Armando Maradona at 17.00 GMT.
The Partenopei dropped from leaders to third place last week with their home defeat to Atalanta, as the injury crisis is taking its toll, but got back on track with Thursday’s 3-2 win over Leicester City in the Europa League.
Victor Osimhen, Kalidou Koulibaly, Fabian Ruiz and Stanislav Lobotka are still out of action, while Lorenzo Insigne and Andre-Frank Zambo Anguissa are back on the bench.
Mertens was rested midweek and returns to lead the attack with support from Hirving Lozano, Adam Ounas and Eljif Elmas.
Coach Luciano Spalletti is in the stands, completing a two-match touchline ban, and Empoli boss Aurelio Andreazzoli used to be his assistant manager at Roma.
The Tuscans have impressed on their travels this season, especially against bigger clubs, while Sebastiano Luperto faces his parent club.
The newly-promoted side are 11th in the table with 23 points, beating the likes of Juventus and Fiorentina already.
Napoli: Ospina; Di Lorenzo, Rrahmani, Juan Jesus, Mario Rui; Demme, Zielinski; Lozano, Ounas, Elmas; Mertens
Empoli: Vicario; Stojanovic, Ismajli, Luperto, Parisi; Zurkowski, Stulac, Henderson; Bajrami; Cutrone, Pinamonti