Napoli hope to continue their perfect start to the season with Victor Osimhen and Lorenzo Insigne, as Dries Mertens is back on the bench against Walter Mazzarri’s Cagliari.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time (18.45 GMT).
The Partenopei have won all five Serie A games so far and need a victory here to retain top spot in the table.
There are some changes from Thursday’s 4-0 win at Sampdoria, as Matteo Politano comes in for Hirving Lozano, while Mertens and Diego Demme recover for a spot on the bench.
Faouzi Ghoulam and Stanislav Lobotka are still out of action.
Osimhen and Insigne continue to lead the attack, with Andre-Frank Zambo Anguissa untouchable in midfield.
Cagliari drew 2-2 at Lazio on Mazzarri’s debut after firing Leonardo Semplici, but were then beaten 2-0 at home by Empoli midweek.
Gabriele Zappa is back after his ban, with Diego Godin and Kevin Strootman returning to the starting XI following injury.
Marko Rog, Damir Ceter, Diego Farias and Paolo Faragò are long-term absentees, but Nahitan Nandez is moved into a more advanced role.
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Fabian Ruiz, Anguissa; Politano, Zielinski, Insigne; Osimhen
Cagliari: Cragno; Caceres, Godin, Walukiewicz; Zappa, Deiola, Marin, Strootman, Lykogiannis; Nandez; Joao Pedro